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Nicotine-free ZYBAN is prescription-strength medicine. ZYBAN is the first nicotine-free pill approved to help you quit smoking, and it is available from your healthcare professional. It's the first pill that can help reduce your urge to smoke. Users of ZYBAN may get The ZYBAN Advantage Plan^® at no additional cost with a prescription for the ZYBAN Advantage Pack. These materials provide information to help you during the quitting process.

Zyban ® is the latest option to help you stop smoking safely and effectively. It's an anti-smoking pill -- that seems to reduce nicotine withdrawal symptoms and the urge to smoke. But Zyban ® (bupropion hydrochloride), approved by FDA in May 1997, has one thing that sets it apart. It contains no nicotine.

Zyban ® is being used by thousands of smokers who want or need to quit smoking. Cigarettes alone kill more than 400,000 Americans each year -- more than AIDS, alcohol, car accidents, murders, suicides, illegal drugs, and fires combined. And smoking can harm not just the smoker but also family members and others who breathe "secondhand smoke." Nicotine in cigarettes is an addictive drug that makes quitting difficult, as confirmed by the 1988 Surgeon General's report on smoking and health.

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Be a Quitter: Help for Smokers
Most smokers know that quitting is not easy. That's because nicotine can be powerfully addictive, both physically and mentally. Quitting "cold turkey" can cause withdrawal symptoms such as fatigue, trouble concentrating, irritability, and cigarette cravings. Fortunately, help is available through various forms of nicotine replacement therapy. There's also a prescription drug called buproprion (trade name Zyban®) that lessens symptoms.

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Zyban Results - Quit Smoking Now
At a time of heightened attention on tobacco and the addictive nature of nicotine, the U.S. Food and Drug Administration (FDA) has cleared for use the first nicotine-free prescription medicine to help people quit smoking. Zyban(TM) (bupropion hydrochloride) Sustained-Release Tablets offer smokers an entirely new approach to quitting smoking.

Zyban, developed by Glaxo Wellcome Inc., is indicated as an aid to smoking cessation treatment and will be available by prescription in six to eight weeks. The medicine will include a personalized patient support program called the Zyban Advantage Plan(TM). The support program will be available at no additional cost to the patient.

Zyban is distinctly different from existing therapies to treat nicotine addiction in that it is a nicotine-free tablet. The current alternative involves replacing cigarettes with either a nicotine patch or nicotine gum.

In addition, patients start Zyban before they quit smoking. They are advised to set a date to stop smoking during the second week of therapy to allow Zyban to reach adequate blood levels. Nicotine replacement products require users to quit smoking completely on the day therapy begins.

Experts in smoking cessation say that smoking is a biochemical addiction, not just a bad habit. While it is not clear how Zyban works, it does effect noradrenergic and/or dopaminergic mechanisms in the brain which have been implicated as pathways of nicotine addiction.

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Gum: Available without a prescription, a nicotine gum such as Nicorette® can be used to reduce cravings whenever you get the urge to light up. Use nicotine gum differently than regular gum. Instead of chewing continuously, chew it just a few times and then leave it "parked" next to the inside of your cheek. This allows the nicotine to pass through the lining of your mouth into your bloodstream.

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Nicorette gum helps you fight cravings and withdrawal symptoms when you quit smoking. We offer Nicorette Gum in starter kits (48ea) up to the large Refill (168es), 2mg or 4mg. Nicotine gum will help you quit smoking!

Nicorette® products can't replace willpower, but they can help you fight your cravings and relieve withdrawal symptoms once you have made a firm decision to do something about your smoking. Indeed if you use Nicorette® to help you stop you can double your chances of succeeding.

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Smoking gives you a steady supply of nicotine. Quitting "cold turkey" shuts it off. Most quitting attempts fail because your body and your brain still crave nicotine.

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The NicoDerm CQ^® patch is different. It's unique design took years to test and perfect. NicoDerm CQ^® is an over-the-counter nicotine patch that you can use over a 10 week period with 3 strengths, or steps so that you may gradually, smoothly reduce the level of nicotine in your body. It can be worn for either 16 or 24 hours.

NicoDerm CQ^® helps you to wean yourself from nicotine, gradually decreasing the dosage until it's low enough for you to discontinue using it altogether. By the end of a 10 week period, you can be nicotine free! But remember, your chances of quitting can improve when you use NicoDerm CQ^® with a counselling program.

Successful quitters report that the excitement, the elation of your transformation as you become a nonsmoker is much more pleasurable than the habit ever was.

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About Smoking Addiction

From the Surgeon General
We now know that cigarettes are addictive and that nicotine is the drug in tobacco that causes addiction. Smokers are compelled to smoke by this addiction to nicotine, but it is the over 4,000 other chemicals in cigarette smoke that cause the most harm. This combination makes cigarettes deadly.

What is it About Nicotine?
When you smoke, nicotine enters the bloodstream through the lungs. It quickly reaches the brain, where it affects certain chemicals that change the way you feel. Eventually, the brain becomes dependent on nicotine to control these chemicals that make you feel "normal."

Am I Addicted?
You may be addicted to cigarettes if you experience one or more of the following signs:

You continue to smoke despite the desire to quit.
You have made a serious, but unsuccessful, attempt to stop using tobacco or permanently reduce the amount you use.
Your attempts to stop smoking have led to physical withdrawal symptoms, including a craving for tobacco, anxiety, irritability, restlessness, difficulty concentrating, headaches, drowsiness, and upset stomach.
You develop a "tolerance" for tobacco. Smoking the same number of cigarettes produces less effect over time, making it necessary to increase the number of cigarettes you smoke to achieve the desired sensation.
You have continued to use tobacco even when you have a serious physical problem (such as cardiovascular or respiratory disease) that you know is worsened by tobacco.

Withdrawal
When smokers who are addicted to cigarettes quit smoking, they may suffer from symptoms that can be psychological, emotional, or physical in nature. This is called withdrawal. They may experience irritability, anxiety, difficulty concentrating, restlessness, or depression. Fortunately for many patients, ZYBAN reduces withdrawal symptoms and the urge to smoke.

Useful Resources to Quit Smoking

You Can Quit Smoking
This is an on-line version of the consumer guide entitled You Can Quit Smoking. This popular Public Health Service brochure provides practical information and helpful tips for those who plan to quit smoking.

Don't Let Another Year Go Up In Smoke: Quit Tips
Are you one of most smokers who want to quit? Then try following this advice.

I QUIT!: What to Do When You're Sick of Smoking, Chewing, or Dipping
Cessation guide targeted to teens who are trying to quit cigarettes or smokeless tobacco. It includes tips for dealing with nicotine withdrawal and for handling the situations that may lead to relapse.

Treating Tobacco Use and Dependence: A Clinical Practice Guideline, Public Health Service
Health care professionals have new evidence and tools to help patients quit using tobacco, according to a report issued by the U.S. Public Health Service (PHS). To obtain this report you can fax 301-594-2800 [Press 1]; or call 1-800-358-9295 for physician materials and a You Can Quit Smoking consumer guide or write to Publications Clearinghouse, P.O. Box 8547, Silver Spring, MD 20907-8547.