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buy rozeremIntroducing...Rozerem, a new development in sleep therapy. To learn more, please read the prescribing information. What purpose does sleep serve in our lives? Is it to refresh the body-or is it to recharge the mind? Experts aren't sure, but something we can all agree on is that sleep is essential for everyone. Exciting advances in neuroscience have provided insight into how the sleep cycle is regulated, which has led to new treatment options for insomnia.

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Question about your order?  Check out our FAQ section

Rozerem™ is indicated for the treatment of insomnia characterized by difficulty falling asleep. Rozerem should be taken within 30 minutes before going to bed and activities should be confined to those necessary to prepare for bed. Rozerem should not be taken with or immediately after a high-fat meal. Studies have not shown an increase in tolerance to Rozerem after a prolonged period of time, meaning a increase in dosage over time is not usually warranted. Unlike all other prescription medications for insomnia, Rozerem is not considered to be a drug with abuse potential, and is not a scheduled drug.

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order rozerem onlineRozerem™ is indicated for the treatment of insomnia characterized by difficulty with sleep onset. Rozerem should not be used in patients with hypersensitivity to ramelteon or any components of the formulation. Rozerem can be prescribed for long-term use. However, failure of insomnia to remit after a reasonable period of time, worsening of insomnia, or the emergence of new cognitive or behavioral abnormalities after taking Rozerem should be evaluated, as such symptoms may be the result of an unrecognized underlying medical disorder. In primarily depressed patients, worsening of depression, including suicidal ideation, has been reported in association with the use of hypnotics.

Rozerem promotes sleep by targeting the SCN.  Rozerem selectively binds to MT1 and MT2 receptors, which are found in the SCN.  This helps promote sleep.  Rozerem does not target GABA receptors.  The selective binding profile of Rozerem may explain the absence of any observed anxiolytic, myorelaxant, and amnesic effects in clinical investigations.

Rozerem Side Effects
buy rozeremRozerem should not be used by patients with severe hepatic impairment, or in patients in combination with fluvoxamine.

Rozerem has not been studied in subjects with severe sleep apnea or severe COPD and is not recommended for use in those populations. Patients should be advised to exercise caution if they consume alcohol in combination with Rozerem.

Rozerem has been associated with decreased testosterone levels and increased prolactin levels. As a result, healthcare professionals should be mindful of any unexplained symptoms possibly associated with such changes in these hormone levels. Rozerem has not been studied in children or adolescents, and the effects in these populations are unknown.

Rozerem should be taken within 30 minutes before going to bed and activities should be confined to those necessary to prepare for bed. Rozerem should not be taken with or immediately after a high-fat meal. Engaging in hazardous activities that require concentration (such as operating a motor vehicle or heavy machinery) after taking Rozerem should be avoided.

The most common adverse events seen with Rozerem that had greater than 2% incidence difference from placebo were somnolence, dizziness, and fatigue.

Rozerem targets the normal sleep-wake cycle.  Sleep is regulated by the internal master clock in the suprachiasmatic nucleus, or the SCN.  Because Rozerem works by selectively binding to receptors in the SCN, it doesn’t act by general central nervous system depression—which may explain the absence of abuse potential.[

FDA Approves Rozerem
buy rozeremThe FDA has approved Rozerem (ramelteon), the first melatonin receptor agonist, for the treatment of insomnia. Unlike other modern sleeping pills, Rozerem was not designated as a controlled substance.

Clinical trials showed no evidence of dependance or abuse of the drug, which was approved at the 8 mg dosage to help patients who suffer from acute or chronic insomnia. Melatonin is believed to be involved in the maintenance
of the circadian rhythm underlying the normal sleep-wake cycle.

"It really is the first of prescription (sleep aid) drugs in recent times to not be scheduled," said Robert Meyer, M.D., director of the pertinent office of drug evaluation at the FDA. "I suspect that will be something that will differentiate it from the others."

Manufactured by Takeda Pharmaceuticals North America, Rozerem works by targeting two receptors, MT1 or MT2, in the suprachiasmatic nucleus, which controls circadian rhythms. The activity of Rozerem at the MT1 and MT2 receptor level is believed to contribute to its sleep-promoting properties, said Takeda.

Takeda Pharmaceuticals North America, Inc. is a new kind of pharmaceutical company. We are dedicated to serving patients by providing innovative products that improve their lives with better healthcare. With a foundation built on the tremendous success of ACTOS® (pioglitazone HCl) as well as a robust, early-stage pipeline, TPNA is poised to realize its vision of becoming a world class pharmaceutical company.

Rozerem Study
New Drug Shows Significant Reduction In Time To Fall Asleep, With No Evidence Of Rebound Insomnia Or Withdrawl Effects. 

Results of a sub-analysis from a Phase III clinical study showed that ROZEREMTM (ramelteon) significantly reduced time to fall asleep in adults with chronic insomnia and showed no evidence of rebound insomnia or withdrawal effects. The results were presented today at the 2006 Annual Meeting of the American Academy of Neurology.

In this placebo-controlled analysis, approximately two-thirds of patients who received 8 mg of ROZEREM experienced at least a 50 percent reduction in the time it took them to fall asleep. Study participants also experienced no rebound insomnia or withdrawal effects following discontinuation of treatment with ROZEREM. Rebound insomnia is the worsening of insomnia symptoms after a person stops taking their insomnia medications.

"These data show that ROZEREM can be effective in helping patients fall asleep faster without rebound insomnia and other withdrawal effects," said Thomas Roth, PhD, director of the Sleep Disorders and Research Center, Detroit, Mich. "This may represent another option for patients who are looking for a sleeping medication that is right for them."

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