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Treat Influenza and Avian Bird Flu
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OSELTAMIVIR - ORAL (oss-el-TAM-eh-veer)
COMMON BRAND NAME(S): Tamiflu
USES:
This
medication is used to treat illness (symptoms) caused by the flu virus
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Tell your doctor your medical history, including: allergies, kidney
problems. This drug may make you dizzy or drowsy; use caution engaging
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Limit alcoholic beverages. This medication should be used only when
clearly needed during pregnancy. Discuss the risks and benefits with
your doctor. It is not known if this drug passes into breast milk.
Consult your doctor before breast-feeding.
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Tamiflu can prevent mortality in mammals-study
 Tamiflu,
a flu drug manufactured by Swiss company Roche, can prevent mortality in
mammals infected with the H5N1 bird flu virus, an experiment on ferrets
by a group of researchers in the United States has found.
However, more studies are needed to determine the optimal dose and
duration of treatment, the research group announced on Wednesday at a
two-day bird flu conference organized by The Lancet medical journal in
Singapore.
The experiment also confirmed the benefits of Tamiflu -- known
generically as oseltamivir -- when given early.
The World Health Organisation has recommended Tamiflu as the best
available line of defence against H5N1 and governments in many countries
have already begun to stockpile the drug in a global effort to combat a
possible pandemic.
Although the disease is still confined largely to birds, it has killed
113 people out of a recorded 205 infections since late 2003 and experts
fear it will trigger the next pandemic once it learns how to transmit
efficiently among people.
As of now, it does not pass easily among people and most human victims
contracted the virus directly from sick birds.
In the study, researchers at the St Jude Children's Research Hospital,
in the U.S. city of Memphis, infected ferrets with the most pathogenic
strain of the H5N1 virus, which has been circulating in Vietnam since
2004.
Ferrets are a species of mammals considered close to humans because they
are very susceptible to influenza and have clinical symptoms that are
similar to those suffered by people, such as diarrhoea, fever and weight
loss.
BENEFITS
According to one of the researchers, Elena Govorkova, all the ferrets
that were given 5 micrograms of oseltamivir per kilogram of body weight
each day survived, while other ferrets in a control group given no drugs
all died.
The lungs, intestines, brains and spleens of those that died were also
found infected with the virus.
The group that was given the drug -- four hours after infection -- had
virus present only in the brains.
To make the test more realistic, the researchers did a parallel
experiment, administering the drug 24 hours after infection and obtained
similar results. Ferrets given the drugs all survived while those given
no medication all died.
The control group was also found with virus-ridden organs, while those
given the drug had virus only in the brains.
"Oseltamivir is good but we still need to know more about optimal
treatment schedule, like dosage, duration and how long we can delay the
treatment after infection," Govorkova said in an interview with Reuters.
The results of the ferret study, which was conducted in January, follows
recent reports saying there was no hard evidence backing the efficacy of
Tamiflu in fighting the virus in people.
UN Urges Fast Planning for Bird Flu
Countries must speed up preparations to deal with an "inevitable" human
influenza pandemic, which could strike soon, a senior U.N. official
warned Tuesday.
David Nabarro, the U.N. coordinator on avian and human influenza, said
countries must work fast because the H5N1 strain of bird flu could
mutate into a form that spreads easily between people much faster than
some officials seem to believe.
Experts fear that a mutation in the bird flu virus, which has ravaged
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worldwide, could spark a pandemic killing millions of people.
"I say to them please act as though it's going to start tomorrow. Don't
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the World Health Organization's annual weeklong executive board meeting.
"It may not be months, it could mean we are going to get human-to-human
transmission tomorrow," he said.
Bird Flu Spreads in Europe
Concerns are mounting in Europe after lab tests confirmed
that an outbreak of bird flu in Turkey and Romania is the same strain as
the one that has killed 60 people in Asia. European poultry consumption
is plunging, and citizens have been rushing to pharmacies to purchase
flu vaccines and anti-viral drugs.
Europeans are becoming increasingly concerned that the H5N1 strain of
bird flu, confirmed in Turkey and Romania, could spread to European
Union countries, amid fears the virus strain could mutate into a form
that can spread among humans.
Britain said Saturday that it would spend $3.5 million for new research
into infectious diseases, including the bird flu virus.
Italy's health minister said his government would spare no resources in
preparing for a possible pandemic.
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