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XENICAL is a prescription medication that can help considerably overweight people lose weight and keep it off. We know that managing your weight can be frustrating, and sometimes you need a little extra support. Support you can't find in a pill alone. To succeed you may have to change the way you feel about food and about your body.

The following information is a summary about XENICAL. It is not intended to replace a doctor's instructions.

(ORLISTAT - ORAL)

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USES
XENICAL is a prescription weight-control medication useful for the long-term treatment of significant obesity.

XENICAL can also help to reduce risk factors, such as high blood pressure, high cholesterol and high blood sugar which, if not treated, could lead to other diseases such as hypertension and diabetes. Each XENICAL capsule contains 120 mg of the active substance orlistat, which acts as a lipase inhibitor.

XENICAL is a weight loss medication that targets the absorption of fat in your body rather than suppressing your appetite. It is useful for long term use and has been shown to be effective for 1-2 years. Dietary fats are inhibited from being absorbed and this allows about 30% of the fat eaten in the mealb to pass through the gut undigested. This helps you to reduce and maintain your weight, as well as to minimize any weight regain.

PRECAUTIONS
This medicine can cause changes in your bowel habits, such as fatty or oily stools, due to the elimination of undigested fat in your stool. XENICAL reduces the absorption of supplements of some fat soluble nutrients, particularly beta-carotene and vitamin E. You should therefore follow your doctor's advice in taking a well balanced diet rich in fruit and vegetables. XENICAL should not be used if you have an allergy to it or suffer from chronic malabsorption syndromes such as sprue or steatorrhea. It is also not intended for use with children or pregnant or nursing women.

DIRECTIONS
XENICAL is taken with each meal (three times daily). Your daily fat intake should be divided equally between these three meals so you will benefit from XENICAL's actions. Your medicine should be swallowed with water.

SIDE EFFECTS
Side effects include loose stools and increased gas or flatulence. These symptoms are generally mild, occur at the beginning of treatment, go away after a short period of time and are usually experienced after meals containing high levels of fat. Normally, these symptoms disappear if you continue treatment and keep to your recommended diet.

IS XENICAL RIGHT FOR ME?
Have you tried dieting, exercise and support groups, but found they never seem to work? Did you lose weight only to quickly gain it back? Your doctor will want to know these things before prescribing a medicine, to make sure that you've considered your options seriously and that your request for XENICAL isn't a hasty one.

XENICAL is a prescription medication, not a magic pill that simply melts pounds away. The nice part about the XENICAL program is that it doesn't involve a complicated diet. In fact, the reduced-calorie diet with no more than 30% calories from fat is the same one recommended by the American Heart Association for all Americans.

If you eat an excessive amount of fat or calories, the excess is stored as fat by the body, resulting in weight gain. When you eat fat, your body breaks it down into its simplest components so that it can be digested.

Unlike other weight-loss drugs you may have heard about that act in the brain or central nervous system to suppress appetite or to speed up metabolism, XENICAL works in your digestive system to block about one-third of the fat in the food you eat from being digested.

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Xenical Studies - Good Results
Data from two new studies were announced today at the Annual Congress of the North American Association for the Study of Obesity (NAASO) in Charleston. The results of one study conducted in high-risk obese patients confirm the results of the one and two year clinical trials that found Xenical to be an effective adjunct to diet in long-term obesity treatment with improvement of some obesity-related risk factors. In another short term study, Xenical was found to block as much as 40% of dietary fat in healthy adults. The same short term study found that the homeopathic diet aid, Chitosan, had minimal effect on the absorption of dietary fat.

Xenical, which acts non-systemically, is the only prescription lipase inhibitor approved by the US Food and Drug Administration for weight loss, maintenance of lost weight and to reduce the risk of weight regain after prior weight loss when used with a reduced calorie diet. Chitosan is an over-the-counter dietary supplement and is not regulated or approved by FDA, nor has its safety and efficacy been established in long term double-blind, placebo-controlled clinical trials.

"A number of major studies have recently highlighted some important facts about obesity: It is more widespread than ever before in this country; it is growing faster than ever before; and it is claiming nearly 300,000 lives each year, " according to Louis J. Aronne, MD, Director of the Comprehensive Weight Control Program at Cornell Medical College. "Given the urgency of this situation, Xenical’s proven effectiveness with diet for medically significant weight loss and weight management means that it is one of our most valuable treatment tools. Physicians and patients alike should be very encouraged by the continued good news about Xenical," continued Dr. Aronne.

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