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Zyban Results - Quit Smoking Now
At a time of heightened attention on tobacco and the addictive nature of nicotine, the U.S. Food and Drug Administration (FDA) has cleared for use the first nicotine-free prescription medicine to help people quit smoking. Zyban(TM) (bupropion hydrochloride) Sustained-Release Tablets offer smokers an entirely new approach to quitting smoking.

Zyban, developed by Glaxo Wellcome Inc., is indicated as an aid to smoking cessation treatment and will be available by prescription in six to eight weeks. The medicine will include a personalized patient support program called the Zyban Advantage Plan(TM). The support program will be available at no additional cost to the patient.

Zyban is distinctly different from existing therapies to treat nicotine addiction in that it is a nicotine-free tablet. The current alternative involves replacing cigarettes with either a nicotine patch or nicotine gum.

In addition, patients start Zyban before they quit smoking. They are advised to set a date to stop smoking during the second week of therapy to allow Zyban to reach adequate blood levels. Nicotine replacement products require users to quit smoking completely on the day therapy begins.

Experts in smoking cessation say that smoking is a biochemical addiction, not just a bad habit. While it is not clear how Zyban works, it does effect noradrenergic and/or dopaminergic mechanisms in the brain which have been implicated as pathways of nicotine addiction.

ZYBAN is a nicotine-free pill. Not a patch. Not a gum.
ZYBAN is the first nicotine-free pill to help you quit smoking. A prescription medicine available only from your healthcare professional, ZYBAN has helped many smokers, even those who have smoked 10 years or more, put down their cigarettes. No one has to know you're using it, except you and your doctor.

You start taking ZYBAN and continue to smoke.
ZYBAN gets you ready to put down your cigarettes. You start taking ZYBAN and set a quit date to stop smoking during the second week. Most people should take ZYBAN for at least 7 to 12 weeks. When you stop smoking, continue to take ZYBAN as recommended by your healthcare professional. One pill 2 times a day can help you break free from smoking.

ZYBAN is priced lower than smoking and some other smoking cessation therapies.^*†
Although your health insurance company may cover smoking cessation therapy, many don't. The graph below shows the approximate price of ZYBAN for 7 weeks of therapy.

Additionally, assuming a pack of cigarettes costs $3.00, a year's worth of smoking one pack a day costs $1,095.00 ... 2 packs a day cost $2,190.00. ZYBAN costs less than cigarettes and is a far better investment in your future than smoking is.

ZYBAN is the most prescribed prescription product for smoking cessation.
Nicotine-free ZYBAN is the most prescribed prescription product for smoking cessation, based on a recent national market research survey reported for prescription drug sales.*

*Source^TM Prescription Audit (SPA); April 2001 to March 2002. Scott-Levin, Inc.

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Zyban Effectiveness
The effectiveness of Zyban as an aid to smoking cessation was demonstrated in two placebo-controlled, double-blind studies involving over 1,500 chronic smokers who smoked at least 15 cigarettes a day. In one study, Zyban was compared to placebo; in the other study, Zyban was evaluated versus placebo, a nicotine patch (Ciba-Geigy Corporation’s Habitrol(R)), and the if Zyban with the nicotine patch. In both studies, all patients received brief individual smoking cessation counseling.

In the study involving the patch, patients treated with Zyban had significantly higher four-week quit rates than those treated with the patch. Patients treated with the combination of Zyban and the patch had significantly higher quit rates than those treated with the patch alone. Quit rates with combination therapy, while higher, were not statistically higher than quit rates with Zyban alone. The four-week quit rates from this study were 23% for placebo; 36% for the patch; 49% for Zyban; and 58% for the combination of Zyban and the patch.

Results from the two studies demonstrated that patients treated with Zyban 300 mg/day had more than a two-fold chance of quitting than patients treated with placebo. Quit rates in clinical trials are affected by the population selected and may be lower for the general population.

For many patients, treatment with Zyban reduced withdrawal symptoms. Withdrawal symptoms showing the most pronounced reductions were: irritability, frustration or anger, anxiety, difficulty concentrating, restlessness, and depressed mood or negative affect. In patients treated with Zyban, there also was evidence of a reduction in craving for cigarettes or urge to smoke.